{"id":1080,"date":"2022-03-13T16:02:00","date_gmt":"2022-03-13T15:02:00","guid":{"rendered":"https:\/\/therapeutic-impact.org\/?p=1080"},"modified":"2022-09-11T16:04:09","modified_gmt":"2022-09-11T15:04:09","slug":"cancers-du-poumon","status":"publish","type":"post","link":"https:\/\/therapeutic-impact.org\/?p=1080","title":{"rendered":"Cancers du poumon"},"content":{"rendered":"\n
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Cancers du poumon : une bact\u00e9rie intestinale pr\u00e9dictive de l\u2019efficacit\u00e9 de l\u2019immunoth\u00e9rapie !<\/div>\n
Les travaux de Laurence Zitvogel, soutenus par la Fondation ARC, montrent que la pr\u00e9sence d\u2019une bact\u00e9rie du microbiote intestinal permet de pr\u00e9dire l\u2019efficacit\u00e9 d\u2019une immunoth\u00e9rapie. Publi\u00e9s ces derniers jours dans la revue Nature Medicine, les r\u00e9sultats obtenus par son \u00e9quipe et ses nombreux collaborateurs, apportent des donn\u00e9es primordiales pour une meilleure prise en charge adapt\u00e9e aux patients atteints de cancers du poumon avanc\u00e9s.<\/div>\n<\/div>\n
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1) Les chercheurs ont pu montrer, par s\u00e9quen\u00e7age de l’ensemble de l’ADN dans les selles de 338 patients, que les bact\u00e9ries du groupe Akkermansia \u2013 dont l\u2019esp\u00e8ce A. muciniphila \u2013 \u00e9taient li\u00e9es au devenir clinique des patients. Les personnes qui pr\u00e9sentaient une certaine proportion de cette esp\u00e8ce dans leur microbiote intestinal b\u00e9n\u00e9ficiaient d\u2019une meilleure r\u00e9ponse aux immunoth\u00e9rapies dirig\u00e9es contre la prot\u00e9ine PD-1 qui leur \u00e9taient administr\u00e9es. Leur survie \u00e9tait aussi significativement meilleure.<\/div>\n
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2) Pour \u00e9tablir un lien entre le microbiote intestinal et la r\u00e9ponse immunologique des patients, les auteurs se sont particuli\u00e8rement int\u00e9ress\u00e9s aux tumeurs des patients. Chez les patients b\u00e9n\u00e9ficiant d\u2019un microbiote riche en A. muciniphila, diff\u00e9rentes populations de cellules immunitaires potentiellement r\u00e9actives semblaient mieux affluer et circuler dans les tumeurs que chez les patients dont le microbiote \u00e9tait d\u00e9pourvu de cette esp\u00e8ce.<\/div>\n
3) Enfin, gr\u00e2ce \u00e0 un mod\u00e8le exp\u00e9rimental in vivo, les chercheurs ont montr\u00e9 qu\u2019un apport de A. muciniphila permettait de modifier le profil du microbiome et de restaurer une sensibilit\u00e9 aux immunoth\u00e9rapies anti PD-1.<\/div>\n
4) En conclusion, les auteurs proposent que leur m\u00e9thodologie de s\u00e9quen\u00e7age soit consid\u00e9r\u00e9e dans une optique pr\u00e9dictive avant traitement aux immunoth\u00e9rapies. Ils sugg\u00e8rent aussi que des essais qui permettraient de modifier les proportions d\u2019 A. muciniphila chez les patients soient envisag\u00e9es, pour sensibiliser les patients pressentis pour recevoir ces immunoth\u00e9rapies.<\/div>\n
\u00a0<\/div>\n<\/div>\n
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Sources :<\/div>\n
https:\/\/www.fondation-arc.org\/cancer-poumon-immunotherapie<\/a>\n
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\u00a0<\/div>\n<\/div>\n<\/div>\n
https:\/\/www.fondation-arc.org\/…\/predire-reponse…<\/a>\n
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\u00a0<\/div>\n<\/div>\n<\/div>\n
Derosa, L. et al ; Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer; Nature Medicine; F\u00e9vrier 2022<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Cancers du poumon : une bact\u00e9rie intestinale pr\u00e9dictive de l\u2019efficacit\u00e9 de l\u2019immunoth\u00e9rapie ! Les travaux de Laurence Zitvogel, soutenus par […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1080","post","type-post","status-publish","format-standard","hentry","category-non-classe"],"acf":[],"yoast_head":"\nCancers du poumon - Therapeutic Impact<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/therapeutic-impact.org\/?p=1080\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cancers du poumon - Therapeutic Impact\" \/>\n<meta property=\"og:description\" content=\"Cancers du poumon : une bact\u00e9rie intestinale pr\u00e9dictive de l\u2019efficacit\u00e9 de l\u2019immunoth\u00e9rapie ! 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