{"id":1091,"date":"2022-05-01T16:09:00","date_gmt":"2022-05-01T15:09:00","guid":{"rendered":"https:\/\/therapeutic-impact.org\/?p=1091"},"modified":"2022-09-11T16:10:28","modified_gmt":"2022-09-11T15:10:28","slug":"bacteries-liees-au-cancer-de-la-prostate","status":"publish","type":"post","link":"https:\/\/therapeutic-impact.org\/?p=1091","title":{"rendered":"Bact\u00e9ries li\u00e9es au cancer de la prostate?"},"content":{"rendered":"\n
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Bonjour \u00e0 tous \"🌼\"<\/span>\"🌻\"<\/span>\"🌼\"<\/span><\/div>\n<\/div>\n
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En ce dimanche matin, TIM tient \u00e0 vous pr\u00e9senter le travail de Hurst et collaborateurs qui est \u00e0 l’origine d’une r\u00e9cente d\u00e9couverte de de bact\u00e9ries qui seraient li\u00e9es au cancer de la prostate. Cette d\u00e9couverte repr\u00e9sente un grand espoir pour mettre au point de nouveaux traitements contre cette maladie!<\/div>\n<\/div>\n
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Le cancer de la prostate fait partie des cancers les plus fr\u00e9quents chez les hommes et est \u00e0 l’origine de plus de 250.000 d\u00e9c\u00e8s annuel \u00e0 travers le monde. Dans le but de comprendre si le cancer est plut\u00f4t agressif, la prise en charge consiste \u00e0 analyser des \u00e9chantillons sanguins ou des pr\u00e9l\u00e8vements de tissus canc\u00e9reux par biopsie. Mais il n’est pas toujours possible de d\u00e9terminer la nature de la tumeur. Or, ce diagnostic est crucial.<\/div>\n
On soup\u00e7onne les bact\u00e9ries de jouer un r\u00f4le dans le d\u00e9veloppement de plusieurs types de cancer, et des associations entre la pr\u00e9sence de bact\u00e9ries particuli\u00e8res et le cancer de la prostate ont \u00e9t\u00e9 signal\u00e9es.<\/div>\n
Pour fournir une meilleure caract\u00e9risation du microbiome de la prostate et de l’urine, et \u00e9tudier le potentiel pronostic des bact\u00e9ries, Hurst et collaborateurs ont \u00e9valu\u00e9s les microbiomes en r\u00e9alisant des cultures ana\u00e9robies, analyses 16S au niveau de la population, RNA-seq et s\u00e9quen\u00e7age de l’ADN du g\u00e9nome entier des \u00e9chantillons d’urine de patients ayant un cancer ou non.<\/div>\n
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En comparant les r\u00e9sultats, ils ont rep\u00e9r\u00e9 la pr\u00e9sence de cinq esp\u00e8ces diff\u00e9rentes de bact\u00e9ries (Anaerococcus, Peptoniphilus, Porphyromonas, Fenollaria et Fusobacterium) li\u00e9es \u00e0 la progression rapide de la maladie. Aucune d’entre elles n’a besoin d’oxyg\u00e8ne pour survivre. Certaines d’entre elles n’avaient jamais \u00e9t\u00e9 d\u00e9couvertes jusqu’\u00e0 pr\u00e9sent. Les hommes qui pr\u00e9sentaient au moins une de ces bact\u00e9ries dans leur urine, dans leur prostate ou dans le tissus canc\u00e9reux, avaient un risque 2,6 fois plus \u00e9lev\u00e9 que les autres de voir leur cancer encore au stade pr\u00e9coce progresser rapidement vers un stade avanc\u00e9 de la maladie.<\/div>\n<\/div>\n
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L’\u00e9quipe s’est d\u00e9sormais fix\u00e9e pour but de d\u00e9velopper un test rapide qui permettrait de d\u00e9tecter une signature pour les cinq bact\u00e9ries identifi\u00e9es. Ce d\u00e9pistage, s’il est r\u00e9alis\u00e9 assez pr\u00e9cocement, permettrait de d\u00e9tecter \u00e0 temps les cancers de la prostate tr\u00e8s agressifs et de gagner du temps pour d\u00e9marrer un traitement. Il existe d\u00e9j\u00e0 ce genre de tests pour Helicobacter pylori dans le cancer de l’estomac, ainsi que des tests pour le papillomavirus.<\/div>\n<\/div>\n
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https:\/\/euoncology.europeanurology.com\/action\/showPdf…<\/a>\n
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https:\/\/www.sciencesetavenir.fr\/…\/decouverte-de…<\/a>\n
\u00a0<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Bonjour \u00e0 tous En ce dimanche matin, TIM tient \u00e0 vous pr\u00e9senter le travail de Hurst et collaborateurs qui est […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1091","post","type-post","status-publish","format-standard","hentry","category-non-classe"],"acf":[],"yoast_head":"\nBact\u00e9ries li\u00e9es au cancer de la prostate? - Therapeutic Impact<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/therapeutic-impact.org\/?p=1091\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bact\u00e9ries li\u00e9es au cancer de la prostate? 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