{"id":1105,"date":"2022-04-24T16:20:00","date_gmt":"2022-04-24T15:20:00","guid":{"rendered":"https:\/\/therapeutic-impact.org\/?p=1105"},"modified":"2022-09-11T16:21:32","modified_gmt":"2022-09-11T15:21:32","slug":"therapies-ciblant-la-voie-myc","status":"publish","type":"post","link":"https:\/\/therapeutic-impact.org\/?p=1105","title":{"rendered":"Th\u00e9rapies ciblant la voie MYC."},"content":{"rendered":"\n
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Les th\u00e9rapies ciblant la voie MYC pourraient \u00eatre essentielles pour inverser la croissance canc\u00e9reuse et restaurer les r\u00e9ponses immunitaires antitumorales chez les patients atteints de cancers induits par MYC.<\/div>\n
En effet, les voies MYC dictent non seulement la physiopathologie des cellules canc\u00e9reuses mais suppriment \u00e9galement la r\u00e9ponse immunitaire de l’h\u00f4te contre ce cancer. Et de ce fait, les prot\u00e9ines myc sont des cibles tr\u00e8s prometteuses comme th\u00e9rapies anti-canc\u00e9reuses.<\/div>\n<\/div>\n
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Les proto-oncog\u00e8nes MYC codent pour une famille de facteurs de transcription qui comptent parmi les oncoprot\u00e9ines les plus fr\u00e9quemment activ\u00e9es. En effet, des aberrations de MYC ou une r\u00e9gulation ascendante des voies li\u00e9es \u00e0 MYC par des m\u00e9canismes alternatifs se produisent dans la grande majorit\u00e9 des cancers. Les prot\u00e9ines MYC sont des r\u00e9gulateurs ma\u00eetres des programmes cellulaires. Ainsi, les cancers avec activation de MYC pr\u00e9sentent de nombreuses caract\u00e9ristiques canc\u00e9reuses n\u00e9cessaires \u00e0 une croissance autonome. Dans les mod\u00e8les pr\u00e9cliniques, l’inactivation de MYC peut entra\u00eener une r\u00e9gression tumorale durable, un ph\u00e9nom\u00e8ne qui a \u00e9t\u00e9 attribu\u00e9 \u00e0 l’addiction aux oncog\u00e8nes. De nombreux agents th\u00e9rapeutiques qui ciblent directement MYC sont en cours de d\u00e9veloppement ; cependant, \u00e0 ce jour, leur efficacit\u00e9 clinique reste \u00e0 d\u00e9montrer. Ces derni\u00e8res ann\u00e9es, des \u00e9tudes ont d\u00e9montr\u00e9 que la signalisation de MYC peut permettre aux cellules tumorales de d\u00e9r\u00e9guler leur microenvironnement et d’\u00e9chapper \u00e0 la r\u00e9ponse immunitaire de l’h\u00f4te.<\/div>\n<\/div>\n
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https:\/\/www.dovepress.com\/getfile.php?fileID=57178<\/a>\n
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https:\/\/pubmed.ncbi.nlm.nih.gov\/35163079\/<\/a>\n
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https:\/\/pubmed.ncbi.nlm.nih.gov\/34508258\/<\/a>\n
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Les th\u00e9rapies ciblant la voie MYC pourraient \u00eatre essentielles pour inverser la croissance canc\u00e9reuse et restaurer les r\u00e9ponses immunitaires antitumorales […]<\/p>\n","protected":false},"author":1,"featured_media":1106,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1105","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classe"],"acf":[],"yoast_head":"\nTh\u00e9rapies ciblant la voie MYC. - Therapeutic Impact<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/therapeutic-impact.org\/?p=1105\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Th\u00e9rapies ciblant la voie MYC. - 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