{"id":1219,"date":"2024-01-30T11:36:00","date_gmt":"2024-01-30T10:36:00","guid":{"rendered":"https:\/\/therapeutic-impact.org\/?p=1219"},"modified":"2025-03-14T11:39:45","modified_gmt":"2025-03-14T10:39:45","slug":"semaine-europeenne-de-sensibilisation-et-de-prevention-du-cancer-du-col-de-luterus","status":"publish","type":"post","link":"https:\/\/therapeutic-impact.org\/?p=1219","title":{"rendered":"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l’ut\u00e9rus;"},"content":{"rendered":"\n\n\n
\n
* Cellule canc\u00e9reuse du rein, all\u00f4 oui, j’\u00e9coute *<\/div>\n
** Les discussions entre les cellules canc\u00e9reuses et leurs voisines participeraient au d\u00e9veloppement des cancers r\u00e9naux **<\/div>\n
*** Cellules canc\u00e9reuses sur \u00e9coute ***<\/div>\n
\u00a0<\/div>\n<\/div>\n
\n
Pour d\u00e9manteler le r\u00e9seau de \u00ab\u00a0malfaiteurs\u00a0\u00bb, il est important de comprendre comment interagissent ses diff\u00e9rents agents. Qui sont les donneurs d\u2019ordres ou les ex\u00e9cutants ? Qui influence qui ? Comment sont pass\u00e9s les messages ?<\/div>\n
L’\u00e9quipe de Vassili Soumelis a enqu\u00eat\u00e9. Leur principal outil ? Le s\u00e9quen\u00e7age des ARN de pr\u00e8s de 28 000 cellules \u2013 prises individuellement \u2013 qui ont \u00e9t\u00e9 pr\u00e9lev\u00e9es dans les tumeurs r\u00e9nales de trois patients et dans des tissus adjacents non canc\u00e9reux.<\/div>\n
Leur travail a consist\u00e9 \u00e0 :<\/div>\n
(1) identifier les messages (quels ARN, en quelle quantit\u00e9 et quelles prot\u00e9ines produites) exprim\u00e9s par les diff\u00e9rents messagers (cellules canc\u00e9reuses ou voisines),<\/div>\n
(2) d\u00e9coder les messages envoy\u00e9s (prot\u00e9ines porteuses d’un message et prot\u00e9ines capables de le r\u00e9ceptionner).<\/div>\n
\u00a0<\/div>\n<\/div>\n
\n
Les chercheurs ont donc identifi\u00e9 plus de 50 canaux utilis\u00e9s par les cellules canc\u00e9reuses pour communiquer avec leurs voisines comme, l\u2019angiogenine et ses prot\u00e9ines r\u00e9ceptrices.<\/div>\n
Des tests plus pouss\u00e9s sur les cons\u00e9quences d’un message angiogenine ont mis en \u00e9vidence son r\u00f4le important dans la prolif\u00e9ration des cellules canc\u00e9reuses et la r\u00e9duction des d\u00e9fenses immunitaires.<\/div>\n<\/div>\n
\n
M\u00eame si des travaux suppl\u00e9mentaires sont n\u00e9cessaires, ce message port\u00e9 par l’angiogenine peut \u00eatre envisag\u00e9 comme cible th\u00e9rapeutique.<\/div>\n<\/div>\n\n\n\n

https:\/\/www.fondation-arc.org\/cancers-du-rein-les-cellules-sur-ecoute<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

* Cellule canc\u00e9reuse du rein, all\u00f4 oui, j’\u00e9coute * ** Les discussions entre les cellules canc\u00e9reuses et leurs voisines participeraient […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1219","post","type-post","status-publish","format-standard","hentry","category-non-classe"],"acf":[],"yoast_head":"\nSemaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l'ut\u00e9rus; - Therapeutic Impact<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/therapeutic-impact.org\/?p=1219\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l'ut\u00e9rus; - Therapeutic Impact\" \/>\n<meta property=\"og:description\" content=\"* Cellule canc\u00e9reuse du rein, all\u00f4 oui, j’\u00e9coute * ** Les discussions entre les cellules canc\u00e9reuses et leurs voisines participeraient […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/therapeutic-impact.org\/?p=1219\" \/>\n<meta property=\"og:site_name\" content=\"Therapeutic Impact\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Therapeutic.IMPACT\/?fref=ts\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-30T10:36:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-14T10:39:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/therapeutic-impact.org\/wp-content\/uploads\/2016\/01\/logo-120.png\" \/>\n\t<meta property=\"og:image:width\" content=\"120\" \/>\n\t<meta property=\"og:image:height\" content=\"39\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"impact\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Therap_IMPACT\" \/>\n<meta name=\"twitter:site\" content=\"@Therap_IMPACT\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"impact\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/therapeutic-impact.org\/?p=1219#article\",\"isPartOf\":{\"@id\":\"https:\/\/therapeutic-impact.org\/?p=1219\"},\"author\":{\"name\":\"impact\",\"@id\":\"https:\/\/therapeutic-impact.org\/#\/schema\/person\/577c4f353c057eed508d7160e8cf916f\"},\"headline\":\"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l’ut\u00e9rus;\",\"datePublished\":\"2024-01-30T10:36:00+00:00\",\"dateModified\":\"2025-03-14T10:39:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/therapeutic-impact.org\/?p=1219\"},\"wordCount\":272,\"publisher\":{\"@id\":\"https:\/\/therapeutic-impact.org\/#organization\"},\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/therapeutic-impact.org\/?p=1219\",\"url\":\"https:\/\/therapeutic-impact.org\/?p=1219\",\"name\":\"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l'ut\u00e9rus; - Therapeutic Impact\",\"isPartOf\":{\"@id\":\"https:\/\/therapeutic-impact.org\/#website\"},\"datePublished\":\"2024-01-30T10:36:00+00:00\",\"dateModified\":\"2025-03-14T10:39:45+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/therapeutic-impact.org\/?p=1219#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/therapeutic-impact.org\/?p=1219\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/therapeutic-impact.org\/?p=1219#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/therapeutic-impact.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l’ut\u00e9rus;\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/therapeutic-impact.org\/#website\",\"url\":\"https:\/\/therapeutic-impact.org\/\",\"name\":\"Therapeutic Impact\",\"description\":\"from basic research to medicinal applications\",\"publisher\":{\"@id\":\"https:\/\/therapeutic-impact.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/therapeutic-impact.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/therapeutic-impact.org\/#organization\",\"name\":\"Therapeutic Impact\",\"url\":\"https:\/\/therapeutic-impact.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/therapeutic-impact.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/therapeutic-impact.org\/wp-content\/uploads\/2016\/01\/logo-120.png\",\"contentUrl\":\"https:\/\/therapeutic-impact.org\/wp-content\/uploads\/2016\/01\/logo-120.png\",\"width\":120,\"height\":39,\"caption\":\"Therapeutic Impact\"},\"image\":{\"@id\":\"https:\/\/therapeutic-impact.org\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/Therapeutic.IMPACT\/?fref=ts\",\"https:\/\/x.com\/Therap_IMPACT\",\"https:\/\/www.youtube.com\/channel\/UCBkbC8oHkDOTKqNHFKbTUMQ\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/therapeutic-impact.org\/#\/schema\/person\/577c4f353c057eed508d7160e8cf916f\",\"name\":\"impact\",\"url\":\"https:\/\/therapeutic-impact.org\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l'ut\u00e9rus; - Therapeutic Impact","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/therapeutic-impact.org\/?p=1219","og_locale":"fr_FR","og_type":"article","og_title":"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l'ut\u00e9rus; - Therapeutic Impact","og_description":"* Cellule canc\u00e9reuse du rein, all\u00f4 oui, j’\u00e9coute * ** Les discussions entre les cellules canc\u00e9reuses et leurs voisines participeraient […]","og_url":"https:\/\/therapeutic-impact.org\/?p=1219","og_site_name":"Therapeutic Impact","article_publisher":"https:\/\/www.facebook.com\/Therapeutic.IMPACT\/?fref=ts","article_published_time":"2024-01-30T10:36:00+00:00","article_modified_time":"2025-03-14T10:39:45+00:00","og_image":[{"width":120,"height":39,"url":"https:\/\/therapeutic-impact.org\/wp-content\/uploads\/2016\/01\/logo-120.png","type":"image\/png"}],"author":"impact","twitter_card":"summary_large_image","twitter_creator":"@Therap_IMPACT","twitter_site":"@Therap_IMPACT","twitter_misc":{"\u00c9crit par":"impact","Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/therapeutic-impact.org\/?p=1219#article","isPartOf":{"@id":"https:\/\/therapeutic-impact.org\/?p=1219"},"author":{"name":"impact","@id":"https:\/\/therapeutic-impact.org\/#\/schema\/person\/577c4f353c057eed508d7160e8cf916f"},"headline":"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l’ut\u00e9rus;","datePublished":"2024-01-30T10:36:00+00:00","dateModified":"2025-03-14T10:39:45+00:00","mainEntityOfPage":{"@id":"https:\/\/therapeutic-impact.org\/?p=1219"},"wordCount":272,"publisher":{"@id":"https:\/\/therapeutic-impact.org\/#organization"},"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/therapeutic-impact.org\/?p=1219","url":"https:\/\/therapeutic-impact.org\/?p=1219","name":"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l'ut\u00e9rus; - Therapeutic Impact","isPartOf":{"@id":"https:\/\/therapeutic-impact.org\/#website"},"datePublished":"2024-01-30T10:36:00+00:00","dateModified":"2025-03-14T10:39:45+00:00","breadcrumb":{"@id":"https:\/\/therapeutic-impact.org\/?p=1219#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/therapeutic-impact.org\/?p=1219"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/therapeutic-impact.org\/?p=1219#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/therapeutic-impact.org\/en\/"},{"@type":"ListItem","position":2,"name":"Semaine europ\u00e9enne de sensibilisation et de pr\u00e9vention du cancer du col de l’ut\u00e9rus;"}]},{"@type":"WebSite","@id":"https:\/\/therapeutic-impact.org\/#website","url":"https:\/\/therapeutic-impact.org\/","name":"Therapeutic Impact","description":"from basic research to medicinal applications","publisher":{"@id":"https:\/\/therapeutic-impact.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/therapeutic-impact.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/therapeutic-impact.org\/#organization","name":"Therapeutic Impact","url":"https:\/\/therapeutic-impact.org\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/therapeutic-impact.org\/#\/schema\/logo\/image\/","url":"https:\/\/therapeutic-impact.org\/wp-content\/uploads\/2016\/01\/logo-120.png","contentUrl":"https:\/\/therapeutic-impact.org\/wp-content\/uploads\/2016\/01\/logo-120.png","width":120,"height":39,"caption":"Therapeutic Impact"},"image":{"@id":"https:\/\/therapeutic-impact.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/Therapeutic.IMPACT\/?fref=ts","https:\/\/x.com\/Therap_IMPACT","https:\/\/www.youtube.com\/channel\/UCBkbC8oHkDOTKqNHFKbTUMQ"]},{"@type":"Person","@id":"https:\/\/therapeutic-impact.org\/#\/schema\/person\/577c4f353c057eed508d7160e8cf916f","name":"impact","url":"https:\/\/therapeutic-impact.org\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=\/wp\/v2\/posts\/1219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1219"}],"version-history":[{"count":1,"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=\/wp\/v2\/posts\/1219\/revisions"}],"predecessor-version":[{"id":1220,"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=\/wp\/v2\/posts\/1219\/revisions\/1220"}],"wp:attachment":[{"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/therapeutic-impact.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}