{"id":863,"date":"2018-10-05T14:34:51","date_gmt":"2018-10-05T13:34:51","guid":{"rendered":"http:\/\/therapeutic-impact.org\/?p=863"},"modified":"2018-10-05T14:34:51","modified_gmt":"2018-10-05T13:34:51","slug":"nouveau-projet","status":"publish","type":"post","link":"https:\/\/therapeutic-impact.org\/?p=863","title":{"rendered":"Nouveau projet!"},"content":{"rendered":"<p>Bonjour \u00e0 tous, aujourd\u2019hui l\u2019\u00e9quipe de Therapeutic IMPACT est fi\u00e8re de vous annoncer que nous allons soutenir un nouveau projet en plus du projet de monsieur Papot. Ce dernier visera \u00e0 soutenir les recherches contre le cancer de la peau du LITEC (<a href=\"http:\/\/litec.labo.univ-poitiers.fr\/\">http:\/\/litec.labo.univ-poitiers.fr\/<\/a>). Pour vous parler du projet, nous avons demand\u00e9 aux investigateurs du projet, qui sont madame Laure Favot Laforge et monsieur Jean Claude Lecron, d\u2019introduire leur sujet\u00a0:<\/p>\n<p>\u00ab\u00a0Les cancers de la peau non m\u00e9lanocytaires sont les cancers les plus fr\u00e9quents chez l\u2019adulte. Ces cancers se d\u00e9veloppent \u00e0 partir des cellules de l\u2019\u00e9piderme appel\u00e9es keratinocytes et sont divis\u00e9s en deux cat\u00e9gories\u00a0: les carcinomes basocellulaires et les carcinomes \u00e9pidermo\u00efdes. Les carcinomes basocellulaires sont constitu\u00e9s de cellules qui ressemblent \u00e0 celles des couches profondes de l\u2019\u00e9piderme alors que les cellules des tumeurs \u00e9pidermo\u00efdes sont plus proches des k\u00e9ratinocytes constituant les couches les plus superficielles.<\/p>\n<p>L\u2019incidence de ces tumeurs keratinocytaires augmente fortement chez les personnes expos\u00e9es au soleil tout au long de leur vie, mais \u00e9galement avec la consommation de tabac et la contraction de certaines infections virales. La majorit\u00e9 des l\u00e9sions se d\u00e9veloppe sur le visage et les mains.<\/p>\n<p>Si les carcinomes basocellulaires restent localis\u00e9s et sujets \u00e0 de bons pronostics, les carcinomes \u00e9pidermo\u00efdes sont beaucoup plus agressifs. Une fois m\u00e9tastas\u00e9s, ils peuvent conduire au d\u00e9c\u00e8s des patients en quelques mois. Ces deux carcinomes sont r\u00e9sistants aux traitements conventionnels de types chimioth\u00e9rapie, radioth\u00e9rapie, le traitement de r\u00e9f\u00e9rence restant aujourd\u2019hui la chirurgie. Ce dernier pr\u00e9sente un pr\u00e9judice esth\u00e9tique d\u00e9pendant de la taille et de la localisation des tumeurs, et ne permet pas le traitement des m\u00e9tastases. Il est donc important de trouver d\u2019autres traitements des carcinomes cutan\u00e9s.<\/p>\n<p>De nombreuses \u00e9tudes ont d\u00e9montr\u00e9 qu\u2019il existe un lien tr\u00e8s \u00e9troit entre l\u2019inflammation et le cancer. Dans les conditions physiologiques, l\u2019inflammation est un processus b\u00e9n\u00e9fique qui \u00e0 la suite d\u2019une infection, d\u2019une blessure, permet \u00e0 l\u2019organisme d\u2019\u00e9liminer les pathog\u00e8nes et de r\u00e9parer les tissus endommag\u00e9s. Dans le cas du cancer, les cellules tumorales peuvent utiliser les m\u00e9diateurs de l\u2019inflammation s\u00e9cr\u00e9t\u00e9s par les cellules du syst\u00e8me immunitaire pour promouvoir leur croissance et leur vascularisation.<\/p>\n<p>Gr\u00e2ce \u00e0 des mod\u00e8les cellulaires et des mod\u00e8les animaux, notre laboratoire \u00e9tudie le r\u00f4le des cytokines (m\u00e9diateurs s\u00e9cr\u00e9t\u00e9s par les cellules du syst\u00e8me immunitaire) sur des k\u00e9ratinocytes afin de mieux comprendre leurs implications dans les maladies inflammatoires cutan\u00e9es (psoriasis, dermatite atopique, infection), la cicatrisation normale ou pathologique et la transformation tumorale.<\/p>\n<p>Nous avons montr\u00e9 qu\u2019une de ces cytokines \u00e9tait capable de modifier le ph\u00e9notype des k\u00e9ratinocytes et notamment de moduler l\u2019activation, la migration et la diff\u00e9renciation cellulaire qui sont des \u00e9tapes importantes dans les m\u00e9canismes de transformation tumorale.<\/p>\n<p>Nous \u00e9tudions maintenant la capacit\u00e9 de cette cytokine \u00e0 moduler le microenvironement inflammatoire et la croissance tumorale in vivo\u00bb<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bonjour \u00e0 tous, aujourd\u2019hui l\u2019\u00e9quipe de Therapeutic IMPACT est fi\u00e8re de vous annoncer que nous allons soutenir un nouveau projet [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":864,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-863","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classe"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nouveau projet! 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